Saturday, October 29, 2011

Entrepenurial science

The grand vision:
Understand viral evolution, both inter and intra host, so we can stop the bastards.

How do I fill in the details?
What do I bring?
Napolean had the art of artillery, thomas had machine learning. And me?
What do I see, which is currently not in the world  yet should be?
Theory of contagion- done
Vaccines- done
Antibiotics- done
Vector control- done
Mathematical epidemiology- done
Emergence of resistance- done
Quasi species- done
Genetics (geno to pheno)- done

Thursday, October 27, 2011

Resistance pathways

We know virus develop resistance to drugs. The interesting cases are when resistance depends on combinations of mutations; mutational pathways.


The concept pathway implies an order. Is there one?
fitness landscapse or seascape?
survival of the fittest or the flattest?
colonizer/competitor dynamics?

What is a reference sequence? Does this define the virus???

Possible titles "Tracing evolutionary pathways through seascapes and bottlenecks"

hmmm-- ship in a bottle, early mariners, exploring, setting up trade outposts???

Wednesday, October 26, 2011

How to do high-impact work

What question do people want answered?

Need to be early or first, find/define an emerging subject.

HIV was a field before Thomas, but not statistical learning and HIV.

Protein docking was a field before Thomas, but not with flexible protein structures.

What is mine?

Thomas suggests integrative model stretching from cell to population

rates of HIV evolution

Prabhav suggested comparing rates of viral evolution within patients to those within a transmission cluster.

We could measure/compare rates of adoptation to treatment to rates of adoptation to a new host.

The confound is that we identify the transmission clusters via genetic distance. It would be easier if we had a known transmission chain.

Alternately, EuResist does have ~6000 cases with two samples taken under one treatment. We could compare rates here with rates after a treatment change.

Yang Lan: The generation that's remaking China

Yang Lan

The Oprah of China.

This talk opened my eyes to the currents flowing in modern China. China faces the same social unrest as we see everywhere in the world today. Dissaffected youth, aware that the system is set up to exploit them, and angry about it.

Tuesday, October 25, 2011

Richard Wilkinson: How economic inequality harms societies

Richard Wilkinson

Stuff we knew before, pulled together into a coherent presentation.

Differences in measures of social well-being (almost ALL such measures) in Western democracies show zero correlation with national GDP. Within each country, however, they show incredibly strong correlation with household income.

Justin Hall-Tipping: Freeing energy from the grid

Justin Hall-Tipping

He presents some of the possibilities offered by carbon nanotubes.

A window which can lighten or darken, in response to a 2V current running for a few microseconds.

Solar power generation.

The idea that each house generates its own electricity this way, and can beam it to its neighbors (as light).

Infrared glasses

NGS review/ Beerenwinkel

Ultra-deep sequencing for the analysis of viral populations
Beerenwinkel and Zagordi,
Curr Opin Virol 2011:1

Very general. Presents the process and challenges. Lists major software for haplotype identificaiton, but does not provide a comprehensive review of their capacities and differences.

filed under beerenwinkel_cov_2011.pdf

competition-colonization dynamics

Competition-colonization dynamics
An ecology approach to quasispecies dynamics and virulence evolution in RNA viruses
Samuel Ojosnegros, Niko Beerenwinkel, and Esteban Domingo

Not the first or best paper on the subject, just the one I read today. A single viral clone, raised in a pure cell culture, evolved into two differnt subpopulations. The phenotypes of the two clades clearly displayed either the competitor (less fit, less virulent, but interfered with replication of the other type) or the colonization (more fit, more virulent) strategy.

stored as ojosnegros2011.pdf

Vision

We see things not as they are, but as we are

Sunday, October 23, 2011

re: thirteen observations

In reply to thirteen observations

Uncle Stan gives several stories illustrating bureaucratic bloat in the US and its human costs. He is more supportive of the Tea Party, because of their goal to get rid of some of this regulation.


Glenn –

As you speculated from your distant perch that Americans don’t seem to be very happy these days, I began to speculate on the reasons why such an impression might be conveyed abroad. As previously stated, I cannot judge the mindset of our country as a whole (where there appears to be massive indifference to many issues that excite the press), but I can relate a couple of recent incidents with which I am very familiar, and which seem symptomatic of others’ frustrations that I read or hear about.

Several years ago, in response to requests for shovel-ready stimulus projects, Baldwin County (where I am located) submitted a grant request for funds to create transit hubs at key points throughout our county (which is many times the geographic size of Luxembourg). It was a relatively modest request for $1.8 million, which in time was approved. However, before the money could be spent, the Federal Transit Administration (FTA) wished to have answered a battery of questions. The County Commission responded. The FTA replied to that with more questions. There ensued a bureaucratic ping-pong game that finally tired out the Commission, which determined the game not worth the candle and then sent the money back. The effect was to prolong the eventual creation of a transit infrastructure with potential for substantial economic development and job creation. It will come about, in the fullness of time, by other means, but at a much slower pace. Meanwhile, the incident created a few new Republican voters. Similar situations elsewhere may account for the slow pace of “stimulus” spending, although a few billion has gone down the drain in failed “green energy” efforts.

My wife, Beth, as you know, is an audiologist (She also qualifies for Intertel, an organization for those with IQs in the upper one percentile). She has practiced that profession with a high and broad degree of skill and success for several decades. A few years back her professional society decided to upgrade the profession’s image by converting its largely MS/MA, mostly female membership to AuD. That, of course, required an expensive return to campus to attain the necessary certification and elevated doctoral designation. Existing practitioners were grandfathered (grandmothered?) in legitimacy, and Beth determined that she was of an age that cost and inconvenience could never be amortized within the remaining span of her career—so fugettaboutit. For awhile this was no problem. She was even appointed by our Governor to a three year term on the state licensing board for audiologists and speech pathologists, where she diligently served with distinction, but not with pay. She came to notice of the VA, which offered her contract (non-Civil Service) work in evaluation of hearing disabilities. She was happy to accept, and submitted the paperwork. It took about eight months of back and forth communication, and more paper, before she was taken on board, part-time. After 18 months she was laid off. There were enough younger, more prestigious, and less knowledgeable AuDs to replace her—although the VA continues to send her $0 payroll statements.

Soldering on, Beth managed to gain some short stints at a Pensacola general and a children’s hospital, as well as with a local hearing aids dealer. But the rules began to change. Now it was required that she obtain a registry number as a Medicare provider. Otherwise, she could not be hired, even to substitute. This entailed a 42 page application, signed off on by an established AuD or MD, as sponsor. No problem, except that long after submission she had not heard a word. She re-did and resubmitted her application—certified mail, signature required (and obtained). Still no response. She wrote to our congressman. He enquired and finally the authorities wrote back that they knew nothing about her. At their suggestion, she tried again. Eventually, several days ago, she and her sponsor each received a several page letter stating that she had submitted an incorrect form (the code designation of which was not among those requested or that she prepared), and was therefore not to be granted the precious number at this time. Meanwhile, she has no work, has a pending offer (one day per week) with another local hearing aids dealer, and must muster her forces to create another application from scratch. Does she find this situation irritating? You bet she does.

The foregoing stories are not atypical. I hear similar stories from others. How does such an atmosphere come about? The short answer is bureaucratic bloat. Within the Federal Civil Service the surest route to promotion is to be overburdened with paper and in need of more assistants. I saw this, myself, as my naval career progressed. People supervised is a key ingredient to pay grade evaluation. Clearly, the more complex, detailed, and pettifogging the paper processing chain can be made, the more people are needed to keep it in operation. The Civil Service has kept this basic principle in place for many, many years. It got worse in the early 60s when JFK, inspired by Wisconsin’s ground-breaking example, issued an executive order authorizing support for Federal employee unionization, at a time when any GS-3 or 4 secretary made far more in salary and bennies than her average civilian counterpart, and had no fear in this life of losing her job. LBJ saluted the idea, and had it made into law. Is it any wonder that career Federal employees (and DC area residents, in general) overwhelmingly vote a straight Democrat ticket, election after election? And what was the percentage of NEW Federal employees added to the rolls after January 2009? Why do you suppose that happened?

While the Hatch Act precludes any sort of open campaigning by Civil Service or military members, the Civil Service unions pour enormous funding into Democrat campaigns. (Military folk may not join unions, and predominantly vote Republican, these days. DoD civilian employees, however, remain in the Democrat camp). It does not matter who sits in the White House or the Congress. Most public policy originates within the administration, and arises from the creative minds of Civil Service staffers who clearly understand the cultural rules that affect their careers. The more they can promote for themselves to do, the better. Appointed officials of either party at the top levels have little time to consider the details, only the broad scope briefed to them on actions that require their endorsement. The result is ever increasing complexity, as the Federal administration grows and grows, and effective decision-making slows and slows. (It ought to be noted that Congress has no Civil Service. It operates on the old-fashioned spoils system, and seems to take pretty good care of itself). Is it any wonder that the Administration makes so much fuss over job security for teachers and first responders at state levels? These constituents carry great emotional appeal and belong to the same unions—an endless source of political allies.

We hear a lot of talk about job creation as a first priority. It’s more of a first talking point, unless government jobs are the subject. Like cancer, the current system has no easy cure. Cancer, however, whether biological or political, eventually kills. We see this throughout Europe today. But why should Americans be unhappy?

Your own pursuits seem to be really interesting. Keep at them. Love, Uncle Stan

re: thirteen observations

In reply to thirteen observations

Hi, Glenn- Thanks. My favorite is no. 7, out of many good points.
7. Someone feeling wronged is like someone feeling thirsty. Don’t tell them they aren’t. Sit with them and have a drink.

My guess is that things will appear to 'go away' during the winter weather, but meanwhile those who were there will be reflecting on the experience and come back some fine spring day next year stronger & better organized than ever, with a whole kit bag of new tactics & approaches.

Meanwhile, everyone here is worried about the euro and whether "those Europeans" will manage to take care of "their mess." Reminds me a bit of the early word for syphilis, which in Spain was known as the French pox, and in France as the Spanish pox. Problem is, in either case it's still the pox, and it spread, and people eventually went crazy and died.

Saturday, October 22, 2011

Advanced/exotic distilling

Lance Winters, at St. George Spirits in Alameda CA, distills crazy things.

Eaux-de-vie is unaged distilate. He has distilled crab, mushroom, seaweed. For things without enough sugar, he first macerates them in high-alcohol spirits (brandy).

He learned more from old perfume books than old distilling books.

3d imaging

Autodesk photofly.

Uses photogrammetry to stich together a collection of 2d images to create a 3d image which can be sent to a manufacturer.

Photofly does the number crunching on the cloud.

You send the resulting image to i.e. Shapeways.

Friday, October 21, 2011

A page from my notebook

I doodled some ideas during the one non-relevant talk at a recent workshop.

Astrid's recorder app



Damn, don't know why the photo looks so crappy! Have a much better version on my phone.

growth of pharaceutical industry

Penicillin was discovered in 1928. WWII required industrial scale production, and 22 companies registered in the US and UK to manufacture it.

Germany today has more than 58000 approved medicines and 1500 manufacturers. javascript:void(0)

Malaria Vaccine

N Engl J Med. 2011 Oct 18.
A Vaccine for Malaria.
White NJ.
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Abstract

It's been a long time coming, and indeed we are still not there yet, but it is becoming increasingly clear that we really do have the first effective vaccine against a parasitic disease in humans. If there are no unforeseen disasters, the RTS,S/AS01 Plasmodium falciparum malaria vaccine should become available in just over 3 years. The World Health Organization (WHO) has already taken the unusual step of indicating that it could recommend this first malaria vaccine for use in some African countries as early as 2015, depending on the full phase 3 trial results that will become available in 2014. . . .


PMID: 22007716

on marx and fetishism

Umair Haque writes:
"Commodity fetishism. A fetishized object is one which is more than a symbol: it's believed to have actually the power the symbol represents (like an idol, or a totem with magical properties). Marx claimed that under industrial age capitalism's rules, commodities became revered talismans, worshipped through transactional exchanges, imbued with mystical powers that give them inherent value — and obscuring the value of and in the very people who've worked labored over them in the first place. It's one of Marx's most subtle and nuanced concepts. Does it hold water? Again, I'll merely pointing to societies in furious pursuit of more, bigger, faster, cheaper, javascript:void(0), nastier, now, whether it's the retail temples of America's mega-malls, or London rioters stealing, not bread, but video games."

To put this in a more modern context: Brands.

The brand as a tribal god. Now there is a concept for ya!

-------------
Ok, you might have spotted the html error. Decided to leave it in because I like the effect

The brand as a tribal god.

Maybe I should publish this as "lost ideas" because I don't have time to coherently follow it up now...

modern tribes, defined by the brands they choose, which makes the brand the tribal god.

company splits/spinoffs

PepsiCo: The case for smaller portions

Mentions several company splits/spinoffs:
Split Pepsi into a drinks firm (Pepsi, Gatorade, Tropicana) and a snack food (Frito-Lay, the best snack food company in the US)

Other splits: Sara Lee, Kraft, and
Fortune Brands, began trading on the New York Stock Exchange. Investors could choose between Fortune Brands Home & Security (locks, windows) and Beam (which makes Jim Beam whiskey).

Electronic weapons

Electromagnetic weapons: Frying tonight

Describes several weapons systems which use an EMP:

the Boeing Growler uses electromagnetics as offensive weapons. The Growler, which first saw action in Iraq in 2010 is a souped-up version of the Super Hornet. It is fitted with five pods. The pods can be used either to spy on enemy communications or to destroy them; to suppress anti-aircraft fire; to disable the electronics of ground vehicles; and to make life so hazardous for enemy aircraft that they dare not fly. The Growler is able to keep its weapons charged up and humming by lowering special turbines into the airstream that rushes past the plane when it is flying. America has ordered 114 of the planes, and has taken delivery of 53.

On ships: BAE Systems, a British defence firm, is building a ship-mounted electromagnetic gun. The High-Powered Microwave, as it is called, is reported by Aviation Week to be powerful enough to disable all of the motors in a swarm of up to 30 speedboats.

The Radio-Frequency Vehicle Stopper, a microwave transmitter the size and shape of a small satellite dish that pivots on top of an armoured car.

Shielding buildings via electrically conductive cement. Global Contour’s mixture includes fibres of steel and carbon would add only $20 to the $150 per cubic metre which ordinary concrete costs.

End of an era

http://www.csmonitor.com/World/Backchannels/2011/1020/How-Muammar-Qaddafi-met-his-end

So now he is gone.

Income decline

A long, steep drop for Americans' standard of living

Not since at least 1960 has the US standard of living fallen so fast for so long. The average American has $1,315 less in annual disposable income now than at the onset of the Great Recession.

From
http://www.csmonitor.com/Business/2011/1019/A-long-steep-drop-for-Americans-standard-of-living

Thirteen Observations

Clipped this from
Thirteen Observations made by Lemony Snicket while watching Occupy Wall Street from a Discreet Distance

Responses:
Dad
Stan

1. If you work hard, and become successful, it does not necessarily mean you are successful because you worked hard, just as if you are tall with long hair it doesn’t mean you would be a midget if you were bald.

2. “Fortune” is a word for having a lot of money and for having a lot of luck, but that does not mean the word has two definitions.

3. Money is like a child—rarely unaccompanied. When it disappears, look to those who were supposed to be keeping an eye on it while you were at the grocery store. You might also look for someone who has a lot of extra children sitting around, with long, suspicious explanations for how they got there.

4. People who say money doesn’t matter are like people who say cake doesn’t matter—it’s probably because they’ve already had a few slices.

5. There may not be a reason to share your cake. It is, after all, yours. You probably baked it yourself, in an oven of your own construction with ingredients you harvested yourself. It may be possible to keep your entire cake while explaining to any nearby hungry people just how reasonable you are.

6. Nobody wants to fall into a safety net, because it means the structure in which they’ve been living is in a state of collapse and they have no choice but to tumble downwards. However, it beats the alternative.

7. Someone feeling wronged is like someone feeling thirsty. Don’t tell them they aren’t. Sit with them and have a drink.

8. Don’t ask yourself if something is fair. Ask someone else—a stranger in the street, for example.

9. People gathering in the streets feeling wronged tend to be loud, as it is difficult to make oneself heard on the other side of an impressive edifice.

10. It is not always the job of people shouting outside impressive buildings to solve problems. It is often the job of the people inside, who have paper, pens, desks, and an impressive view.

11. Historically, a story about people inside impressive buildings ignoring or even taunting people standing outside shouting at them turns out to be a story with an unhappy ending.

12. If you have a large crowd shouting outside your building, there might not be room for a safety net if you’re the one tumbling down when it collapses.

13. 99 percent is a very large percentage. For instance, easily 99 percent of people want a roof over their heads, food on their tables, and the occasional slice of cake for dessert. Surely an arrangement can be made with that niggling 1 percent who disagree.

Tuesday, October 18, 2011

Reed Kroloff on modern and romantic architecture

modern and romantic architecture

Damn, can't remember why I liked this one! Maybe because he presented some cool new buildings.

We need to re-do our house, think through how we actually use it. Right now it is set up on a very, very old model-- kitchen, dining room, TV room. Leaving no space for office style work, which also needs to happen. I am thinking kid's homework, etc.

Monday, October 17, 2011

Is humanity a disease?

Looked at from the point of view of other organisms, humankind therefore resembles an acute epidemic disease, whose occasional lapses into less virulent forms of behavior have never yet sufficed to permit any really stable, chronic relationship to establish itself.

from the introduction to Plagues and Peoples by William McNeill, 1976

Dan Barber: How I fell in love with a fish

Dan Barber

Dan Barber is a chef, searching for a tasty and sustainable fish species for his restaurant. He had one, farmed in mid-ocean, until he learned that its primary feed was chickens; the bits that don't sell in grocery stores were turned into pellets and fed to those fish.

Then he found an organic fish farm. It is based on a healthy ecosystem, so they do not need to feed the fish-- the fish get their food from the environment. They measure the health of the farm by the health of the predators. And the farm filters water; its output is cleaner than its input.

But HE NEVER TELLS US THE NAME OF THE FISH!!

How are WE supposed to support it if we cannot buy it?

Sunday, October 16, 2011

Urban trees

Mike's idea. An app which lets people geotag trees and the tree's health status.

I see lots of benefits. People would feel more involvement with "their" trees, and local governments could better visualize/optimze their urban forestry.

See also Natalie Jeremijenko, who proposes small urban actions which collectively have a huge impact.

Saturday, October 15, 2011

Freelancing and outsourcing

Odesk for outsourcing

Glassdoor to get inside info on companies

Freelance.com

Friday, October 14, 2011

Schumpeter: Getting on the treadmill

The Economist

Insurance companies who use monitoring to reward clients who have healthy behavior-- swipe your gym card 3x a week and get a reduction in your premiums.

These ideas come from emerging economies.

Thursday, October 13, 2011

Misha Glenny -- The Dark Market

Reporting on organized cybercrime. Same guy who wrote McMafia.
http://www.thersa.org/events/audio-and-past-events/2011/dark-market-cyber-thieves,-cyber-cops-and-you

The Reign of the One Percenters

By Christopher Ketcham, writing in Orion Magazine Sept/Oct 2011.

Christopher is a native New Yorker with great anger towards the bankers.

I want Léa to understand what New York, my birthplace and home, once beloved to me, is really about. Because I’m convinced that the beating heart of the city today is not its art galleries, its boutiques, its restaurants or bars, its theaters, its museums, nor its miserable remnants in manufacturing, nor its creative types—its writers, dancers, artists, sculptors, thinkers, musicians, or, god forbid, its journalists.

“Here,” I tell her, standing in the canyons of world finance, “is what New York is about. Sociopaths getting really rich while everyone else just sits on their asses and lets it happen.”
This is the rage of impotence. Quotes Mark Twain
“The human race is a race of cowards; and I am not only marching in that procession but carrying a banner.”
New York's income inequality is 15th from the bottom (on a list of 134 countries), with the top 1% taking 44% of all income, and average income of 3.7 million. In terms of population, the top 1 percent is 34K households, or 90,000 people. Almost all of them work in finance.

The author recalls the extremes and the crashes of 1873 and 1884, which lead Pres. Cleveland to observe that "the wealth and luxury of our cities [is] largely built upon undue exactions from the masses of our people.” This lead to the first ever Labor Day parade, and the candidacy of Mayor Henry George: "Political liberty requires economic liberty." Yet it took until the crash of 1929 to finally unseat the rentier class.

And today, the drive for money above all else is destroying creativity in NY. The creative types leave, they cannot afford the rent to stay, they make no money.

The model is from advertising: find what people want to hear, then echo it in the news so that they will be attracted to hear more of it. “If you want to know what’s really going on in a society or ideology, follow the money,” writes author Jaron Lanier. “If money is flowing to advertising instead of musicians, journalists, and artists, then a society is more concerned with manipulation than truth or beauty. If content is worthless, then people will start to become empty-headed and contentless… Culture is to become precisely nothing but advertising.”

Affluenza

the seeking of money and possessions as markers of ascent up the competitive ladder; the worship of celebrities as heroes of affluence; the haunted desire for fame and recognition; the embrace of materialistic excess that, alas, has no future except in the assured destruction of Planet Earth and of every means of a sane survival.

quoted from Christopher Ketcham
http://www.orionmagazine.org/index.php/articles/article/6470

Television

The Television Watchers start thinking alike, looking alike, buying alike, and they don’t know why.

observation by an old handyman.

Echos a similar comment made by a Greek when TV first came to their village. "Now we will all be the same"

Rory Sutherland: Sweat the small stuff

Rory Sutherland

Getting the small details right is what makes great design work, and what makes things memorable.

People in power like to make big efforts, but the relationship between money spent/effort and outcome/impact is not linear.

Examples: Hotel in Stockholm whose elevator buttons are "garage", then "house", "jazz", "classic"-- i.e. they let you pick the elevator music. Memorable, low cost. Counterexample: elevator in Heathrow which connects two floors but has no buttons-- people panic.

Example: Virgin Airlines first class salt/pepper shakers which have "stolen from VA 1st class" embossed in their bottom.

An issue is people with power and a big budget feel they need to use the budget, and are thus drawn to expensive projects. Wants to create a new office which has great power and a small budget.

Cross-link to article in the October Wired; using city maps made by blind people to improve urban settings. Maps from blind people highlight the walkability of a city.
Claudia Folska

Wednesday, October 12, 2011

Johanna Blakley: Lessons from fashion's free culture

Johanna Blakley

The fashion industry doesn't have copyright or patents.

This talk is a great argument for free culture

Tuesday, October 11, 2011

Deborah Rhodes: A tool that finds 3x more breast tumors

Deborah Rhodes

Traditional mammography doesn't work well for dense breasts, but having dense breasts is a significant risk factor for the disease. She offers a new technology, molecular breast imaging (MBI), which is better for dense breasts

She works at the mayo clinic
http://mayoresearch.mayo.edu/staff/rhodes_dj.cfm

Alex Steffen: The shareable future of cities

Alex Steffen

Focus on building the dream neighborhood, not the dream home.

He gives the now-classic power-drill example (used on average for 15 minutes over its entire life, yet everyone has one. Because under our current pricing scheme, the convenience of ownership outweighs the horrible inneficiency costs). See also Rachel Botsman

If you make it so people would rather walk than drive --dense living--, then people don't buy cars, which saves huge amounts of emmisions and costs (think: roads, parking lots, etc).

If you make buildings which are heated/cooled by natural forces, then you don't need central heating systems.

Friday, October 7, 2011

Gun notes

Dan Wesson barrels: http://www.ewkarms.com/
and custom grips http://lbcustomgrips.com/
pre 1989 ONLY!!

"best" bullet depends on what I can handle. Grant Cunningham says "I load up the trusted and proven .38 Special +P 158 grain all lead semi-wadcutter hollowpoint."

Revolver reload technique is here:
http://www.grantcunningham.com/revolver-reload.html

Another clip:
If you take self defense seriously, however, at some point you have to ask about the "after part" - what happens after you've discharged your gun at an assailant. Marty is the President of the Armed Citizens Legal Defense Network, which has just released his booklet titled "What Every Gun Owner Needs to Know About Self Defense Law".
http://www.armedcitizensnetwork.org/images/stories/Hayes-SDLaw.pdf

Beautiful handmade grips:
http://www.handmadegrips.com/index.php?route=product/all
http://www.badgercustomgrips.com/smith_and_wesson_pistol_grips.php

http://www.bang-inc.com/
http://en.wikipedia.org/wiki/Jerry_Miculek

Maintenance. The Jerry Kuhnhausen books, available from Amazon or Heritage Gun Books (the publisher)
http://www.coltparts.com/
Avoid colts made during the UAW strike (1986-1990).

Highway Patrolman model 27,28

Purchase via
http://www.armslist.com/

Media apperances:
http://www.imfdb.org/wiki/Colt_Python
http://www.imfdb.org/wiki/Smith_%26_Wesson_Model_686

Books:
brianenos.com Practical Shooting : Beyond Fundamentals
Refinement and Repetition, Dry-fire Drills for Dramatic Improvement [Spiral-bound] b Steve Anderson
Fast and fancy revolver shooting by Edward McGivern
Gunsmithing. Pistols and Revolvers by Patrick Sweeney

maybe: Combat Shooting with Massad Ayoob

http://www.doublealpha.biz/ for EU based purchases. Books, supplies, etc


Lubes:
http://steelshieldtech.com/mainpage/retail-product-weapon-shield.html
or
Break-Free CLP
or
Sentry Products tuf-guard
www.toolshop.de -> accessories

Importing to the US. Try Simpson LTD. http://www.simpsonltd.com/export.php

Thursday, October 6, 2011

mauritus, home of the dodo bird

Margaret Wertheim on the beautiful math of coral

Margaret Wertheim

You can crochet hyperbolic space, and prove non-euclidean geometry.

Number of straight lines through a point outside a line which do not touch the line:

0: sphere
1: Euclidean space
inf: hyperbolic space

Examples: the Klein bottle.
Also, thisperspective projection of a dodecahedral tessellation in H3.
Four dodecahedra meet at each edge, and eight meet at each vertex, just like a cubic tessellation in E3 (clipped from Wikipedia):





She gets there by crocheting a coral reef. Many animal have hyperbolic structure.

Conclusion: we need to create play-tanks, like think-tanks, which let one play with concrete forms of abstract ideas.

Wednesday, October 5, 2011

Oren Harman, The Price of Altruism 6 Sept 2011

Oren Harman

Amazing creatures, the social amoebae. Individuals, who, when resources become scarce, organize themselves into a slug-like blob, though they also have cheaters

Mirron neurons erase the difference between self and other. This gives a true biological basis for altruism.

Mr. Harman is a fan of George Price, who, along with working on the Manhattan Project and CAD, formulated the Price Equation, which proves and better expresses Fisher's fundamental theorem of natural selection,
"The rate of increase in fitness of any organism at any time is equal to its genetic variance in fitness at that time."

Tuesday, October 4, 2011

eudaimonia

Human flourishing.

Umair Haque is pretty big on the word.

Terrorists as little gods (?)

Hurricane Katrina resulted in 20 times the amount of insurance claims than 9/11, yet the government response to 9/11 must be hundreds if not thousands of times more expensive than the resources put into rebuilding New Orleans.

Why is this? Why does one disaster get so much attention and the other is forgotten in a year?

We view nature as an amorphous force, with no agency. Terrorists, on the other hand, have a face, a name.

The ancients invented gods to personify the forces of nature which surrounded them, providing a framework for understanding the chaos of the world. There were no random events, but rather the work of the gods.

Are terrorists then the minor gods of our time?

Monday, October 3, 2011

Ellen Dunham-Jones: Retrofitting suburbia

Ellen Dunham-Jones

Another "suburbia is dead" bit, with some great ideas on how to revitalize these areas. Build transport hubs (bus/rail links), turn the hubs into faux urban areas, and turn everything not on a transit corridor into greenspace.

Suburbia now has more childless families than families with children.

Interesting stat, from 2007, that most suburbanites were spending 29% of their budget on housing and 32% on transportation. Crazy, if it is true

Sunday, October 2, 2011

Beyond regulatory capture

From Simon Johnson, 'The Quiet Coup", Altantic Monthly May, 2009.

Mr. Johnson is a former chief economist for the IMF. As such, he has been involved in financial rescue packages for a number of emerging economies. The general problem is that the oligarchs have taken on outsized risks, which have gone bad. The solution is for the government to let a few of them fall. This is politically difficult, as the oligarchs have power.

He writes: "In a primitive political system, power is transmitted through violence, or the threat of violence: military coups, private militias, and so on. In a less primitive system more typical of emerging markets, power is transmitted via money: bribes, kickbacks, and offshore bank accounts. Although lobbying and campaign contributions certainly play major roles in the American
political system, old-fashioned corruption—envelopes stuffed with $100 bills—is probably a
sideshow today, Jack Abramoff notwithstanding.

Instead, the American financial industry gained political power by amassing a kind of cultural
capital—a belief system ... Washington already believed that large financial institutions and free-flowing capital markets were crucial to America's position in the world."

Article saved as Johnson2009IMF.pdf

LINES, A poem by Astrid

All kinds of lines swirl and bend,
I wonder if they'd like a friend.
Big and small,
short and tall.
I wonder who can count them all.

Saturday, October 1, 2011

America the addict

So I have been telling people for years that the decline I see in the US is just like the decline I saw in my friend Dave Evans, who was addicted to cocaine. This guy puts it so well:
source (http://www.vanityfair.com/business/features/2011/11/michael-lewis-201111)

An edited cut and paste:

The road out of Vallejo passes directly through the office of Dr. Peter Whybrow, a British neuroscientist at U.C.L.A. with a theory about American life. He thinks the dysfunction in America’s society is a by-product of America’s success. In academic papers and a popular book, American Mania, Whybrow argues, in effect, that human beings are neurologically ill-designed to be modern Americans.

The human brain evolved over hundreds of thousands of years in an environment defined by scarcity. It was not designed, at least originally, for an environment of extreme abundance. "The problem is that our passions are still driven by the lizard core of our mind." We are set up to acquire as much as we can of things we perceive as scarce, particularly sex, safety, and food.” Even a person on a diet who sensibly avoids coming face-to-face with a piece of chocolate cake will find it hard to control himself if the chocolate cake somehow finds him. We cannot think down the road when we are faced with the chocolate cake.

The richest society the world has ever seen has grown rich by devising better and better ways to give people what they want. The effect on the brain of lots of instant gratification is something like the effect on the right hand of cutting off the left: the more the lizard core is used the more dominant it becomes. "We have lost the ability to self-regulate, at all levels of the society. The $5 million you get paid at Goldman Sachs if you do whatever they ask you to do—that is the chocolate cake upgraded.”

The succession of financial bubbles, and the amassing of personal and public debt, Whybrow views as simply an expression of the lizard-brained way of life. A color-coded map of American personal indebtedness could be laid on top of the Centers for Disease Control’s color-coded map that illustrates the fantastic rise in rates of obesity across the United States since 1985 without disturbing the general pattern. The boom in trading activity in individual stock portfolios; the spread of legalized gambling; the rise of drug and alcohol addiction—it is all of a piece. Everywhere you turn you see Americans sacrifice their long-term interests for short-term rewards.

What happens when a society loses its ability to self-regulate, and insists on sacrificing its long-term interest for short-term rewards? How does the story end? “We could regulate ourselves if we chose to think about it,” Whybrow says. “But it does not appear that is what we are going to do.” Apart from that remote possibility, Whybrow imagines two outcomes. The first he illustrates with a true story, which might be called the parable of the pheasant. Last spring, on sabbatical from the University of Oxford, he was surprised to discover that he was able to rent an apartment inside Blenheim Palace, the Churchill family home. The previous winter at Blenheim had been harsh, and the pheasant hunters had been efficient; as a result, just a single pheasant had survived in the palace gardens. This bird had gained total control of a newly seeded field. Its intake of food, normally regulated by its environment, was now entirely unregulated: it could eat all it wanted, and it did. The pheasant grew so large that, when other birds challenged it for seed, it would simply frighten them away. The fat pheasant became a tourist attraction and even acquired a name: Henry. “Henry was the biggest pheasant anyone had ever seen,” says Whybrow. “Even after he got fat, he just ate and ate.” It didn’t take long before Henry was obese. He could still eat as much as he wanted, but he could no longer fly. Then one day he was gone: a fox ate him.

The other possible outcome was only slightly more hopeful: to hit bottom. To realize what has happened to us—because we have no other choice. “If we refuse to regulate ourselves, the only regulators are our environment,” says Whybrow, “and the way that environment deprives us.” For meaningful change to occur, in other words, we need the environment to administer the necessary level of pain.

Unfinished stories on viral quasispecies and Darwinian views of evolution (Mas et all 2010)

Quasispecies is a form of memory, "Molecular memory is structured as subgroups of variants having lower frequency of representation than teh most abundant or master sequences but that are presetn in a higher percentage than the ephemeral variants resulting from continuing erroneous replication."

Memory sequences may become master when the environment changes.

"A quasispecies evolves with a vision (the capacity of sensing and follwoing a fitness gradient, an apparent ability of selection to see ahead), and is supported by the effecdts of memory"


My take: The virus is a quasispecies, a dynamic everchanging cloud. That is the element on which selection takes place, and it is its amorphous character which allows it to thrive. This may also be why they live on the edge of mutational catastrophy, because this gives them the most freedom of motion around their sequence space.

J. Mol. Bio 2010, 397.

DOI> 10.1016/j.jmb.2010.02.005

Sexual networks and disease transmission liljeros 2003

Reviews implications of social network analysis on epidemiology of sexually transmitted diseases.

The core of the review is that STDs do not exhibit the weakly homogenous mixing which underlies the standard epidemiological model.

Traditional approach: divide into subpopulations based on number of different partners. Assortive mixing-- swingers have many contacts with other swingers. This generates a faster spread and smaller size epidemic. Dissasortive interaction has swingers mixing it up with virgins, which leads to slower initial spread and a larger epidemic. Most studies find that the assortive mixing model best fits reality (refs 17 and 18). Extending these models to include all the dimensions of human interaction soon results in a model with too many dimensions to be analytically solvable (ref 30, 31).

Claims first SNA paper was by Jacob Moreno, who drew sociograms of relationships (Moreno and Jennings, "Statistics of social configurations", Sociometry 1938). HIV is what convinced the world that the network perspective is crucial (A.S. Klovdahl, Networks and pathogens, Sex. Transm. Dis. 2001).

The Resina data is similar to other patterns-- a large network but few large components (J.L. Wylie, A. Jolly, Patterns of chlamydia and gonorrhea infection in sexual networks in Manitoba, Canada, Sex. Transm. Dis. 2001)

And then the review peters out. The only real finding is that diseases in scale-free networks are always epidemics, because the variance of the degree distribution is infinite.