New word Pleiotropy - when a single gene influences multiple phenotypic traits.
Like so many other biological networks, the degree distribution follows a power law. Network hubs have a high degree of pleiotropy, with the number of genetic interactions for a hubsignificantly correlated with the number of distinct annotated functions. Does this work in reverse? This suggests that genetic network hubs play key roles in the integration and execution of morphogenetic programs.
In addition, hubs tend to be expressed at higher mRNA levels, genetic interaction degree corresponds positively with gene conseravation and negatively with copy number volatility.
Layout was done using Cytoscape, with an edge-weighted spring embedded algorithm
Fun stuff!
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