Making sense of the hairball

by Natasa Przulj

Network topology contains biological data. Topological structures are preserved across species

Wrote software for network alignment:
GRAAL
MI-GRAAL
basic approach is seed and extend.
MI allows nodes to have similarity values, which provide additional information for the alignment.

degree of node and connection pattern defines 'graphlets'
Graph crunch software.

See also Isorank, by Bonnie Berger's lab.