Janet Thornton- evolution of enzyme mechanisms and functional diversity

Grand vision- an arrow showing the pathway for bioinformatics:
Dictionary-- the parts (genes,proteins,etc)
Thesaurus-- the interactions
Circuit diagram-- the biological networks
Atlas-- where (and when) it happetns.

We are only at the thesaurus stage

Data doubles every 5 months

Comparing, clustering, evolution of bio chemistry.

Most enzyme evolution (90%) is within the same enzyme class, adopting to either a new substrate or new product.